The American Society for Biochemistry and Molecular Biology's Journal of Biological Chemistry has published "Phospholipase D in cell signaling: From a myriad of cell functions to cancer growth and metastasis," an article by Julian Gomez-Cambronero, Ph.D., professor of biochemistry & molecular biology, as part of a minireview series on phospholipase D (PLD) and cancer. Professor Cambronero served as a guest editor of the series along with George M. Carman, JBC associate editor, and created the cover illustration. Phospholipase D signaling plays a critical role in cell growth and proliferation, vesicular trafficking, secretion and endocytosis. Cancer invasion and metastasis rely heavily on cellular motility, and, as such, they have put PLD at center stage in cancer research. This minireview series highlights some of the molecular mechanisms that evidence the emerging tumorigenic potential of PLD, the role of the microenvironment, and putative connections with inflammation. PLD represents a potential target for the rational development of therapeutics against cancer and other diseases. View the article here (PDF).
