Department of Biochemistry and Molecular Biology (BMB)

Dr. Michael Leffak's Laboratory Published in "Nature Chemical Biology"

Dr. Michael Leffak's laboratory published in Nature Chemical Biology that probing trinucleotide repeat structures using engineered zinc-finger nucleases provides evidence that DNA hairpins form in vivo and are linked to replication-dependent genomic instability. Instability of (CTG)-(CAG) repeats in microsatellite DNA has been linked to numerous neurological diseases.