November 6, 2026
9 a.m.–5:30 p.m.
Student Union Atrium and Discovery Room
The CoSM Festival of Research, sponsored by Leidos Inc., is a day-long event that provides opportunities for graduate and undergraduate students and postdocs to explore research, scholarship, and careers. Check below for a schedule of the day's events!
Schedule
| Time | Event |
|---|---|
| 9 a.m. | Welcome (Discovery Room)
|
| 9:15–11 a.m. | Podium Talks Session 1 (Discovery Room) |
| 11 a.m.–noon | Poster Session 1 (Atrium) |
| Noon–1 p.m. | Lunch break (Union Market; lunch vouchers provided to participants and volunteers) |
| 1–2:15 p.m. | Poster Session 2 (Atrium) |
| 2:15–3 p.m. | Q&A with Employer Panel and Raffle (Discovery Room) |
| 3–4:30 p.m. | Podium Talks Session 2 (Discovery Room) |
| 4:30–5 p.m. | Nibble and Network (Raider Landing - Outside the Bookstore) |
| 5–5:30 p.m. |
Awards Presentation (Discovery Room)
|
Podium Speakers
Session 1 — 9:15 a.m.
- Dillynn Blevins | Invasive Plants & Caterpillar Communities
- Erica Cox | Revisiting An American Advantage
- Dawson Smiley | One more will (not) hurt: A lexical analysis of moral reasoning in a threshold problem
- Nihal Annaparthi | Platelet-activating factor-receptor signaling inhibits the efficacy of targeted Signal transducer and activator of transcription 3 pathway inhibitors in non-small cell lung cancer models
- Rani Chattopadhyay| Kv2.1, SK2, and SK3 Expression Increases in Non-Prefrontal Cortex Neurons of the C9orf72 ALS-FTLD model
- Aleena Elizebeth | Do Orai Channels Conduct Outward Current?
- Jordan Hamdan | Reduction in Persistent Inward Currents as a Candidate Mechanism for Fatigue-Induced Weakness in Aging and Dynapenia
- Preethika Mandalapu | Characterization of HaCaT ASM Knockout Cells in Response to Environmental Stress
- Sainidhi Sridhar | One more will (not) hurt: A lexical analysis of moral reasoning in a threshold problem
Session 2 — 3 p.m.
- Lindsay Rowland | Does honeysuckle leaf blight and blight-associated tissue loss alter the competitive impact of Amur honeysuckle on northern spicebush?
- Abdulghafar Alagili | Targeting FBXL16 via dTAG-Mediated Degradation Reveals Its Role in Cullin-7 Dependent Regulation of Tumor Suppressor FBXO31.
- Vivian Egan | A Comprehensive Approach to Assessing Fatigue and the Impacts of Transcutaneous Vagus Nerve Stimulation.
- Nicholas Hall | MVRC Supernormality Does Not Correspond to Increased Muscle Fiber Excitability
- Denish Maharjan | Therapeutic Evaluation of Lipin1 in the D2.mdx Mouse Model of Duchenne Muscular Dystrophy
- Rachel Mansfield | From Sounds to Sampling Space: Defining Effective Detection Distance for Secretive Marsh Birds
- Cheri Wright | Behind the Silence: Exploring Loneliness, Social Support, and Gender-Role Conflict Among College Students
- Mariah Slaughter | Let it grow! A measure of tree growth influenced by soil phosphorus and mycorrhizal association.
- Amelia Whorton | Real-time Cognitive workload tracking with Garmin
All sessions are located in the Discovery Room.
Posters (Sorted by Last Name)
All posters are located in the Student Union Atrium
| Name | Title | Poster number | Scholarship Funding |
| Shreeya Adhikari | Cross-Device Heart Rate Mapping | 43 | |
| Layan Al-Askari, Yashu Dhamija | Longitudinal Response to Biologic Therapy in a Young Adult With Severe Eosinophilic Asthma: A Case Study | 32 | |
| Aassem Aldughaim | Inhibition of Reducing Sugar-Induced Oxidative Stress in Pancreatic Beta Cells by Nitric Oxide | 33 | |
| Ancita Andrade | Assessing Student Confidence and CER Competencies: A Pre-Post Analysis of Argumentation Outcomes | 48 | |
| Ujol Bata Shrestha | Pairing Ferrocene Redox Activity with Platinum–NHC Cytotoxicity: Ligand Synthesis toward Dual-Mode Anticancer Complexes | 25 | CoSM Research Scholars |
| Rola Benammar | Distinct types of muscle stiffness in myotonia congenita | 34 | |
| Supriya Bhukya | The impact of Platelet-activating factor-receptor signaling and microvesicle particles in the cytotoxic efficacy of Aurora kinase inhibitors in Lung Cancer | 2 | |
| Lawrence Bowteng | Futures in chemistry- Empowering Young minds | 57 | WestRock Scholars |
| Makaya Brashares | Bristle flies of the Tropical Andes: Biodiversity, diversification, and mimicry | 69 | |
| Kiyah Burroughs | Geologic Time and Evolution Education: utilizing interactive teaching methods to build scientific literacy | 55 | |
| Eleanor Chase | Aerobic biodegradation of polyurethanes through the co-metabolism of volatile organic compounds. | 61 | WestRock Scholars |
| Vaidehi Chaudhari | Music & Attention: Examining Familiarity, Pitch & Task Performance. | 50 | |
| Akhila Chintala | Efficacy of Repurposed Chlorpromazine in Glioblastoma | 12 | CoSM Research Scholars |
| Ryanne Cimatu | Microplastics in Municipal Wastewater: Quantification, Fate, and Microbial Associations in West-Central Ohio Treatment Facilities | 66 | |
| Jack Clark | Functional inhibitors of acid sphingomyelinase reduced microvesicle particle release in photosensitive models | 3 | |
| Justin Conley | Speciation genomics of the Green-winged Teal (Anas crecca) complex. | 62 | |
| Hadassah S Davidson | Neuromuscular Junction Function in Hyperkalemic Periodic Paralysis | 4 | |
| Meenu Devi | Efficacy and safety of chemoradiotherapy in small cell lung cancer | 35 | |
| Widad El-Zein | ALS-Linked MATR3 Causes Cell Size Enlargement in Budding Yeast | 17 | CoSM Research Scholars |
| Tim Fauley | Effects of Fatigue on Multitasking Behavior and Performance | 49 | |
| Emily Gelske | Does size matter: How prairie size impacts pollinator diversity and services | 68 | CoSM Research Scholars, WestRock Scholars |
| Syaron Ghising | Differential Effects of Perfluorooctanoic Acid (PFOA) on a Human B-cell line (CL-01) and its hs1.2 Variants | 31 | |
| Madeline Greene | Same species, different setting: Evaluating root-associated fungal pathogen communities across endemic and planted populations of Pinus radiata | 64 | WestRock Scholars |
| Pooneh Hajmirza Mohammadi Kamalabadi | Lipin1 Restoration Improves Muscle Pathology and Excitation–Contraction Coupling Ca²⁺ Handling in mdx Mice | 42 | CoSM Research Scholars |
| Nimashi Herath | Rational Design and Development of Novel Ferrocene-Based N-heterocyclic Carbene Gold Complexes as Potential Anticancer Agents | 26 | CoSM Research Scholars |
| Caroline Hunt | Investigation of Calcium Fluoride Nucleation and Crystal Growth Chemistry Through Ion Selective Electrode Potentiometric Titrations: Thermodynamics vs Kinetics | 44 | WestRock Scholars |
| Eric Jackson | Potential distribution, energy dissipation, and path entropy of of transport in disordered media | 46 | |
| Mychaela Janzow | Investigating the role of ZFP36L1 and ZFP36L2 on host immune response and antiviral activity against RNA viruses | 19 | |
| Rylie Jeanneret | Media Exposure and Traditional Gender Role Beliefs | 51 | |
| Shamvabi Jha | Effects of Non-Cytotoxic Hexavalent Chromium Exposure on Antibody Production in Human B Cells | 20 | |
| Vijayalakshmi Jogi | Development of a high-throughput assay for analyzing damaged cell-free DNA and identifying pharmacological modulators | 21 | CoSM Research Scholars |
| Krishna Joshi | The impact of psychological support on treatment outcomes in cancer patients | 52 | |
| Kirtan Kachhadiya | Platelet-activating factor-receptor-dependent microvesicle particles modify the cytotoxic efficacy of signal transducer and activator of transcription 3 inhibitors in Non- Small Cell Lung Cancer | 5 | |
| Nishat Khalid | Lipin1 Regulates Satellite Cell Function and Skeletal Muscle Regeneration in Dystrophic Muscle | 6 | |
| Kinza Khan | Green Synthesized Nanoparticles to detect Antimony in bottled Water. | 58 | |
| Cohen Kohorst | Evaluating the Impact of Bioethics Education on Undergraduate Ethical Perspectives | 54 | |
| Ajay Kumar | FBW7 and TIP60 Differentially Regulate MDM2 in Squamous Cell Carcinoma | 1 | |
| Kimaya Labde | Acid Sphingomyelinase dependent MVP release following thermal burn injury and photodynamic therapy. | 13 | CoSM Research Scholars |
| Ellen Lee | Preliminary results of Avian Influenza screening of Passerine birds from Poland | 63 | WestRock Scholars |
| Puja Luitel | Redox-Active Ferrocenyl Bis(NHC) Nickel(II) Anticancer Agents | 27 | |
| Maggie Mann | DNA Dendrons: Programmable Carriers for Protein Therapeutics | 28 | |
| Megha Ann Manoj | Stress Granule Proteins Rescue ALS-Associated FUS toxicity in Yeast | 18 | |
| Avianna Gay | Drop wise Fluoride Delivery Reveals Hidden Kinetics in Potentiometric Precipitation Titrations: Rethinking Pre nucleation Signatures in CaF₂ Systems | 59 | WestRock Scholars |
| Arian McNeil | Ranolazine Attenuates C-Fiber Hyperexcitability More Effectively Than Suzetrigine | 22 | |
| Alissa Meeks | Mapping Forensic DNA Practice: A database of SOPs | 14 | |
| Shahd Mohamed | FBXL16 Depletion Activates p38-Mediated Apoptosis in Lung and Breast Cancer Cells | 7 | |
| Sonali Mohan | Storm Interval Scale Study of Run-off for Dry Catchments with Threshold Soil Water Content | 47 | |
| Darwin Muñoz | Mitochondria-Targeted Ionic Liquids | 29 | |
| Angie Muse | Crayfish-mediated improvement of stream and riparian health following removal of Lonicera maackii | 67 | |
| Kwaku Nti Nyarko | Determination of detect heavy metals in water using a green synthesized silver nanoparticles modified glassy carbon working electrode. | 60 | WestRock Scholars |
| Emma Orsi | Preference Choice and Memory Testing in Eisenia fetida | 53 | |
| Parth Panara | Redox-Active Gold Complexes as Next-Generation Cancer Therapeutics | 41 | CoSM Research Scholars |
| Dhara Patel | Role of platelet-activating factor-receptor signaling in Dichloroacetate efficacy in Lung cancer | 8 | |
| Matthew Pickrell | Effects of extracellular Mg2+ and Ca2+ on cell diameter, proliferation and cytotoxicity | 36 | Considine Scholars |
| Sima Rai | Ferrocene–NHC Palladium(II) Hybrids: Design, Synthesis, and Anticancer Potential | 30 | |
| Yasmeen Razi | Studying the Protein Interactions of α-synuclein using a modified Yeast Two-Hybrid Approach | 15 | |
| Isabel Reyna | Identifying Factors That Influence Ypt1-Mediated Suppression of α-Synuclein Toxicity | 16 | |
| Rebecca Riley, Andrew Deutsch | Intrinsic motoneuron properties in controls of a new C9orf72 animal model of ALS | 39 | |
| Cooper Roberts | Effects of Chronic Sodium Channel Blockade on Muscle Weakness in Hyperkalemic Periodic Paralysis | 37 | |
| Riley Rush | Codetection of Arsenic and Selenium with Polyaniline Modified Electrodes | 56 | |
| Diksha Saini | Does zinc deficiency cause renal inflammation? | 23 | |
| Mansi Sharma | The role of the platelet-activating factor-receptor pathway in the cytotoxic response to epidermal growth factor receptor inhibitor in non-small cell lung cancer | 9 | |
| Hiya D. Shukla | Enabling PEI gene vector tracking by covalent attachment of a blue-light emitting, benzoxazole-based chromophore | 40 | |
| Jamie Stopczynski | Pinpointing Cryptic Species: Acoustic Localization of Secretive Marsh Birds | 70 | CoSM Research Scholars, WestRock Scholars |
| Sushaen Prabhala | Investigating Tacrolimus-Induced Kidney Dysfunction and Irreversible Kidney Damage via Dietary Administration | 38 | |
| Chandler VanBuskirk | The F-Box Proteins FBXL16 and FBXO45 co-regulate Estrogen-Receptor-Alpha in ERα+ Breast Cancer and Mediate response to Fulvestrant treatment | 10 | |
| Katie Weddle | Lights Out Dayton- monitoring avian window strikes | 65 | |
| Sonu Yadav | Rab GTPase-mediated membrane remodeling and α-synuclein toxicity in yeast | 24 | |
| Zachary Kuntz | Lipin1 restoration suppresses cardiomyopathy progression in Duchenne Muscular Dystrophy | 11 | |
All Abstracts (Sorted by Last Name)
Abstracts for the 2026 Festival of Research at Wright State University
Abstracts ordered alphabetically by last name
TALKS:
Talk #15 | Abdulghafar Alagili | alagili.2@wright.edu
Research Advisor: Weiwen Long, Ph.D.
Targeting FBXL16 via dTAG-Mediated Degradation Reveals Its Role in Cullin-7 Dependent Regulation of Tumor Suppressor FBXO31.
It remains a mystery how FBXL16 upregulates oncogenic signaling in KRAS-mutant lung adenocarcinomas (LUAD). In the current study, we discovered that FBXL16 interacts with and destabilizes tumor suppressor FBXO31 by forming a SKP1/Cullin-7–based E3 ligase complex. FBXL16 upregulates DUSP6, a phosphatase for ERK1/2, by destabilizing FBXO31, which targets DUSP6 for polyubiquitination and degradation. Induced degradation of FBXL16 using dTAG-13 chemical led to an increase in FBXO31, a decrease in DUSP6, hyperactivation of ERK1/2, and inhibition of LUAD cell growth. These findings reveal a critical role for FBXL16 in controlling FBXO31/DUSP6/ERK1/2 signaling and support FBXL16 as a potential therapeutic target in LUAD.
Talk #12 | Nihal Annaparthi | annaparthi.2@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Platelet-activating factor-receptor signaling inhibits the efficacy of targeted Signal transducer and activator of transcription 3 pathway inhibitors in non-small cell lung cancer models
Co-Authors: Anita Thyagarajan, Ravi P. Sahu
Platelet-activating factor-receptor (PAFR) and signal transducer and activator of transcription 3 (STAT3) signaling pathways promote tumorigenesis and therapy resistance in non-small cell lung cancer (NSCLC). However, there is no solid evidence demonstrating crosstalk between these two pathways. As clinical STAT3 inhibitors are developed, we hypothesized that PAFR pathway would modulate STAT3 inhibitor efficacy in NSCLC. We demonstrate that STAT3 inhibitors alone decrease NSCLC survival in a dose- and time-dependent manner. Importantly, PAFR activation attenuated, whereas PAFR antagonism synergistically enhanced, the anti-proliferative and anti-tumorigenic effects of STAT3 inhibitors. These findings highlight the PAFR-STAT3 axis as a potential therapeutic target for NSCLC.
Talk #7 | Dillynn Blevins | blevins.79@wright.edu
Research Advisor: John Stireman, Ph.D.
Invasive Plants & Caterpillar Communities
Co-Authors: John Stireman
Invasive plant species are a major ecological threat to native ecosystems. These invasives often displace native species and do not contribute to ecosystem services. Two widespread invasive shrubs in Southwestern Ohio are Elaeagnus umbellata (Autumns Olive), and Lonicera maackii (Amur Honeysuckle). To assess their contribution to the local ecosystem and native food webs, we surveyed caterpillar diversity and herbivory levels on these invasive plants compared to native plants. Our results suggest Elaeagnus umbellata shows similar herbivory and diversity when compared to natives. However, contrary to our initial beliefs, Lonicera maackii hosts lower diversity and herbivory levels than all focal plants.
Talk #5 | Rani Chattopadhyay | chattopadhyay.3@wright.edu
Research Advisor: Sherif Elbasiouny, Ph.D.
Kv2.1, SK2, and SK3 Expression Increases in Non-Prefrontal Cortex Neurons of the C9orf72 ALS-FTLD model
Co-Authors: Sherif Elbasiouny
Cognitive and behavioral symptoms resulting from Frontotemporal Lobar Degeneration (FTLD) have been extensively reported in Amyotrophic Lateral Sclerosis (ALS) patients for over a century. This research aims to expand research on ALS-FTLD and potassium channel expression within the C9orf72 model of the most common ALS-FTLD mutation. Looking at Kv2.1, SK2, and SK3 expression on cortical cells, we found that aside from the prefrontal cortex, Kv2.1 expression increased with disease progression. SK2 and SK3 both showed increased expression, regardless of brain area. In conclusion, potassium channel expression increases within non-prefrontal cortex areas of the C9orf72 model.
Talk #11 | Erica Cox | cox.436@wright.edu
Research Advisor: Dan Krane, Ph.D.
Revisiting An American Advantage
Co-Authors: Dan Krane, Joelle Vuille, Simon Ford, Bill Thompson
This study examines how forensic DNA evidence is used to establish facts in criminal cases in the United States, the United Kingdom, Switzerland and Japan. Critics of adversarial systems often see European court-appointed experts as a remedy for partisan bias, yet little research has tested how well non-adversary systems handle scientific evidence. Equality-of-arms concerns and Japan's prosecution-dominated practice add further contrasts. Building on earlier US-Swiss work, we will interview attorneys, judges and DNA experts about activity level propositions, probabilistic genotyping and electronic data integrity. Findings may identify remaining challenges and help assess the fairness and efficiency of accusatorial and inquisitorial systems.
Talk #1 | Vivian Egan | egan.17@wright.edu
Research Advisor: Joshua Fiechter, Ph.D.
A Comprehensive Approach to Assessing Fatigue and the Impacts of Transcutaneous Vagus Nerve Stimulation.
Co-Authors: Joshua Fiechter
Fatigue is among the primary contributors to performance degradation and accidents in high-stakes operational environments. Traditional performance assessments typically rely on isolated task metrics and aggregate descriptive statistics, such as mean reaction time. However, these methods often fail to account for the compensatory strategies that operators employ to maintain primary task performance at the expense of secondary task stability and physiological cost. This work argues that traditional metrics mask latent degradation, and proposes the use of Multitasking Throughput (MT), an efficiency metric designed to measure performance on multiple tasks at once, to capture the strategic trade-offs inherent in cognitive resource competition. Utilizing an archival dataset from a study on Transcutaneous Vagus Nerve Stimulation (TVNS), this research evaluates the effectiveness of neuromodulation as a fatigue countermeasure while simultaneously validating the sensitivity of the proposed efficiency metric, Multitasking Throughput (MT). This work demonstrates that MT may provide a more granular and accurate superior detection of fatigue-induced performance shifts. Incorporating MT to past and future experimental designs may offer a superior diagnostic tool for human factors research.
Talk #16 | Aleena Elizebeth | elizebeth.2@wright.edu
Research Advisor: J. Ashot Kozak, Ph.D.
Do Orai Channels Conduct Outward Current?
Co-Authors: Aleena Elizebeth, Soumya Bajpai, Bailey Cordill, Xiaowei Hou, J. Ashot Kozak
Store-operated calcium entry through Orai/STIM channels is essential for immune response. Orai1 currents typically show strong inward rectification, whereas Orai3 and TRPM7 channels exhibit a prominent outward current. We investigated whether outward current is an intrinsic property of Orai1 gain-of-function variants or arises from endogenous HEK293 channels. Patch-clamp electrophysiology recordings were performed in Orai1-knockout HEK293 cells overexpressing Orai1 gain-of-function variants with 5–6 mM bathing calcium. Majority of cells showed inward rectification without detectable outward current. However, a minority displayed outward current above +40 mV. These findings suggest that outward current may arise from endogenous channels rather than Orai1 itself. Further experiments will identify its source.
Talk #17 | Nicholas Hall | hall.652@wright.edu
Research Advisor: Mark Rich, Ph.D.
MVRC Supernormality Does Not Correspond to Increased Muscle Fiber Excitability
Co-Authors: Nicholas J. Hall, Jethro Choi, Adam Deardorff, Mark M. Rich, Karen Suetterlin
Muscle velocity recovery cycles (MVRCs) assess skeletal muscle excitability, but the mechanism underlying supernormality remains unclear. We tested whether MVRC supernormality reflects increased intrinsic membrane excitability in isolated mouse extensor digitorum longus muscle. Intracellular current-clamp recordings measured action-potential threshold at baseline and 20 and 80 ms after conditioning stimulation. Current threshold increased at both intervals, indicating reduced excitability during the expected supernormal period. Additionally, 50 µM BTS abolished or blunted supernormality under several conditions. These findings suggest that MVRC supernormality does not directly reflect increased membrane excitability and that muscle contraction contributes to the observed recovery-cycle signal in skeletal muscle.
Talk #18 | Jordan Hamdan | hamdan.16@wright.edu
Research Advisor: Sherif Elbasiouny, Ph.D.
Reduction in Persistent Inward Currents as a Candidate Mechanism for Fatigue-Induced Weakness in Aging and Dynapenia
Fatigue is a critical marker in aging that highlights the inability of older adults with progressive loss of muscle function (dynapenia) to activate muscles voluntarily. This ability is generated by persistent inward currents (PICs), driven by voltage-gated sodium and L-type calcium channels on spinal motor neurons that aid in muscle force and generation. We hypothesize a reduction in PICs due to fatigue with aging. To determine this, we will conduct electrophysiology experiments to assess PIC amplitude before and after fatigue. Identifying the mechanism underlying fatigue-induced weakness will provide insights into neurotherapeutic strategies for preserving motor function in older adults.
Talk #13 | Denish Maharjan | maharjan.26@wright.edu
Research Advisor: Hongmei Ren, Ph.D.
Therapeutic Evaluation of Lipin1 in the D2.mdx Mouse Model of Duchenne Muscular Dystrophy
Co-Authors: Pooneh Hajmirza Mohammadi Kamalabadi, Hongmei Ren
Duchenne muscular dystrophy (DMD) is a fatal X-linked disorder caused by dystrophin loss, leading to progressive muscle degeneration, fibrosis, and dysfunction. Lipin1, a phosphatidic acid phosphatase involved in lipid metabolism and muscle membrane integrity, is reduced in dystrophic muscle. We evaluated lipin1 restoration in D2-mdx:lipin1 transgenic mice and the therapeutic potential of MyoAAV-lipin1 gene delivery. Muscle-specific lipin1 restoration improved muscle strength, reduced fibrosis, and enhanced respiratory function. Systemic MyoAAV3-lipin1 delivery improved skeletal and diaphragm muscle function, with greater functional benefits than glucocorticoid treatment. These findings support lipin1 restoration as a potential therapeutic strategy for DMD.
Talk #14 | Preethika Mandalapu | mandalapu.26@wright.edu
Research Advisor: Jeffery B. Travers, Ph.D.
Characterization of HaCaT ASM Knockout Cells in Response to Environmental Stress.
Co-Authors: Kimaya labde, Christine M. Rapp, Karen M. Henkels, Wenfeng zhang, Suvechha Bhandari, Avital savin, Jeffery B. Travers
Environmental stressors trigger keratinocytes to release microvesicle particles (MVPs), yet how this process is regulated remains unclear. Acid sphingomyelinase (ASM) drives ceramide production and membrane signaling, suggesting possible involvement. We characterized HaCaT ASM knockout (ASM KO) cells and compared them with wild type cells after thermal burn injury, UVB irradiation, and cold exposure at −20°C and −80°C. ASM KO cells released fewer MVPs after burn, UVB, and −20°C injuries; no differences were noted following −80°C stress. These preliminary findings reveal both ASM-dependent and ASM-independent mechanisms of stress-induced MVP release, supporting pharmacologic ASM inhibitors as potential treatments for acute environmental injuries.
Talk #9 | Rachel Mansfield | mansfield.26@wright.edu
Research Advisor: Volker Bahn, Ph.D.
From Sounds to Sampling Space: Defining Effective Detection Distance for Secretive Marsh Birds
Co-Authors: Brendan Shirkey, Nate Stott, Volker Bahn
Secretive marsh birds are challenging to monitor but conservation depends on accurate population data. Understanding acoustic sampling space is necessary for designing effective monitoring programs. We used controlled playback experiments in open-field and marsh environments to quantify acoustic detection over distance because detection distance uncertainty can bias population estimates. Detection probability declined with distance and varied among species and call types, resulting in species-specific effective detection distances. These results will guide the integration of acoustic data collected using different methods across wetlands to improve occupancy estimates and link those estimates to habitat metrics useful for wetland management and conservation.
Talk #6 | Lindsay Rowland | rowland.85@wright.edu
Research Advisor: Don Cipollini, Ph.D.
Does honeysuckle leaf blight and blight-associated tissue loss alter the competitive impact of Amur honeysuckle on northern spicebush?
Co-Authors: Don Cipollini
The fungal pathogen Insolibasidium deformans causes a disease known as honeysuckle leaf blight in the leaves of invasive Lonicera maackii (Amur honeysuckle). Blight results in progressive photosynthetic tissue loss. We performed a greenhouse experiment to determine whether blight and blight-associated tissue loss reduce the competitive impact of L. maackii on native northern spicebush (Lindera benzoin). Visible blight infection incidence was low, so we supplemented blighted plants with manual defoliation to simulate tissue loss. Preliminary results show that spicebush grown with damaged honeysuckle grew faster than spicebush grown with healthy honeysuckle in ambient conditions, with no such pattern observed in shade.
Talk #8 | Mariah Slaughter | slaughter.31@wright.edu
Research Advisor: Megan Rua, Ph.D.
Let it grow! A measure of tree growth influenced by soil phosphorus and mycorrhizal association.
Co-Authors: Madeline Greene, Rebecca Snell, Jared DeForest, Megan Rúa
The future composition of Ohio’s forests are determined by the survival and growth of trees in the forest today. Understanding the abiotic and biotic factors, like soil phosphorus availability and the mycorrhizal association of trees, that influence tree growth through time are integral to predicting the forests of tomorrow. We found that binned five-year relative growth rates of two genera of temperate trees varied with tree mycorrhizal type and soil phosphorus availability (F7, 98.4 = 5.9, p < 0.01). These findings suggest that nutrient availability and the strategy used to acquire nutrients will be instrumental in determining future forest compositions.
Talk #3 | Dawson Smiley | smiley.29@wright.edu
Research Advisor: Valerie L. Shalin, Ph.D.
One more will (not) hurt: A lexical analysis of moral reasoning in a threshold problem
Co-Authors: Dawson Smiley, Morgan R. Borders & Valerie L. Shalin
242 participants recruited from Prolific rated the morality and appropriateness of 8 different moral reasoning scenarios. Each participant provided a description of the scenarios and a justification for their rating, along with demographic variables including education level, age and ideology. Lexical analysis of the explanations for one of the threshold scenarios with cumulative harm is consistent with an aggregated analysis across scenarios. A preliminary analysis using non-overlapping confidence intervals in the proportion of quantifiers, and language concerning power, cognition, pro-social behavior, and moral reasoning suggest interactions between the contextual variables of the experimental task, and protagonist and participant ideology.
Talk #1 | Sainidhi Sridhar | sridhar.14@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Relevance of platelet-activating factor-receptor signaling in the efficacy of Salinomycin
Co-Authors: Sainidhi Sridhar, Anita Thyagarajan, Ravi P. Sahu
Non-small cell lung cancer (NSCLC) remains a clinical burden due to drug resistance, necessitating novel therapeutic strategies. Salinomycin, a polyether ionophore, inhibits cancer stem cells and tumor-promoting pathways, whereas Platelet-activating factor-receptor (PAFR) signaling promotes NSCLC. However, the impact of PAFR on salinomycin response remains unknown, prompting us to investigate this interaction and potential combination approaches. We demonstrate that salinomycin alone decrease NSCLC survival and migration in a dose- and time-dependent manner. Importantly, PAFR activation enhanced, whereas PAFR antagonism attenuated migratory and tumorigenic effects of salinomycin. These findings highlight PAFR inhibition as a novel approach to enhance salinomycin efficacy in NSCLC.
Talk #4 | Amelia Whorton | whorton.10@wright.edu
Research Advisors: William Romine, Ph.D. and Tanvi Banerjee, Ph.D.
Real-time Cognitive workload tracking with Garmin
Cognitive workload is the cognitive resources available to do tasks. When workload is too high, performance declines and fatigue can increase. Here we present EngagementTracker, an application that captures continuous biometrics from Garmin wearables. We also present a reinforcement learning model that predicts cognitive workload and the optimal state of engagement, flow state.
Talk #2 | Cheri A. Wright | wright.704@wright.edu
Research Advisor: Sarah Jackson, Ph.D.
Behind the Silence: Exploring Loneliness, Social Support, and Gender-Role Conflict Among College Students
Co-Authors: Dr. Sarah Marie Jackson
Loneliness is more than simply being alone. This study examined predictors loneliness among 137 college students (39 men, 93 women). Social support, psychological distress, and gender expectation conflict were negatively correlated with loneliness. Hierarchical regression analyses revealed that social support, psychological distress, and gender-role conflict remained significant predictors, while social media use and mentorship did not explain additional variance in loneliness. Significant gender differences were in the opposite direction from what was hypothesized, with men expressing less loneliness and more social support than women. These findings could suggest that gender-related expectations surrounding emotional expression might influence self-reported loneliness.
POSTERS:
Poster #43 | Shreeya Adhikari | adhikari.228@wright.edu
Research Advisor: Tanvi Banerjee, Ph.D.
Cross-Device Heart Rate Mapping
Wearable devices such as Apple Watch and Garmin make it easy to continuously track heart rate, but the measurements from different devices do not always agree. This study explores these differences using heart rate data collected simultaneously from both devices during different physical activities. After aligning and preparing the data, a neural network is used as a baseline, followed by a physics-informed neural network (PINN) that incorporates heart rate dynamics into the learning process. The study aims to determine whether heart rate measurements from one wearable device can be mapped to another, helping improve consistency across wearable platforms.
Poster #32 | Layan Al-Askari| al-askari.2@wright.edu
Research Advisors: Yashu Dhamija, Ph.D. (UC) Patrick Sonner, Ph.D. (WSU)
Longitudinal Response to Biologic Therapy in a Young Adult With Severe Eosinophilic Asthma: A Case Study
Co-Authors: Yashu Dhamija
Severe eosinophilic asthma can remain difficult to control despite therapy. This longitudinal case study examines treatment response in a young adult with severe eosinophilic and allergic asthma across multiple biologic therapies and continued long-term treatment. Clinical outcomes were evaluated using eosinophil counts, pulmonary function tests, medication use ,exacerbations, and healthcare utilization. Continued biologic therapy has been associated with improved blood biomarkers and a substantial reduction in hospital visits, although recent exacerbations demonstrate persistent disease complexity. Multiple comorbid conditions further complicate clinical management. Ongoing immune evaluation and bronchoscopy findings highlight the importance of individualized, multidimensional approaches to severe asthma management.
Poster #33 | Aassem Aldughaim | aldughaim.2@wright.edu
Research Advisor: Kazi Islam, Ph.D. (Central State)
Inhibition of Reducing Sugar-Induced Oxidative Stress in Pancreatic Beta Cells by Nitric Oxide
Co-Authors: Aassem Aldughaim, Kazi Islam
Diabetes induced oxidative stress damages insulin-producing pancreatic β-cells. This study investigates whether the nitric oxide (NO) donor sodium nitrite (NaNO2) protects β-cells from glucose induced oxidative and inflammatory damage. Using a hamster pancreatic β-cell model, cells were exposed to 75 mM glucose to induce marked oxidative stress measured via TBARS formation and subsequently treated with NaNO2. Results indicate NaNO2 treatment significantly reduced glucose induced oxidative stress and cytotoxicity while increasing cell viability. Furthermore, NaNO2 inhibited the inflammatory NF-κB signaling pathway and reduced TNF-α expression. These findings suggest NO donors offer a protective mechanism for β-cells against diabetes-associated damage.
Poster #48 | Ancita Andrade | andrade.12@wright.edu
Research Advisor: William Romine, Ph.D.
Assessing Student Confidence and CER Competencies: A Pre-Post Analysis of Argumentation Outcomes
Co-Authors: William Romine
This study evaluates the impact of multimodal text sets on student Claim-Evidence-Reasoning (CER), argumentation confidence, and science reading interest. The goal of the text sets is to give students the opportunity to interact with a scientific anchor text, and then scaffold texts which help students understand the anchor text when they returnto it. Pre- and post-intervention data from over 870 students demonstrated significant improvements in overall CER skills (p < 0.001) and argumentation confidence (p = 0.005). However, students' interest in reading about science showed no significant change. Mixed-effects models further indicated that special education status significantly influenced all measured outcomes but that their gains were comparable to their peers. To efficiently scale and validate these complex student assessments, subsequent phases of this research will evaluate the reliability and comparative effectiveness of possible AI-scored models versus traditional human-scored evaluations of student CER performance.
Poster #25 | Ujol Bata Shrestha | batashrestha.2@wright.edu
Research Advisor: Kuppuswamy Arumugam, Ph.D.
Pairing Ferrocene Redox Activity with Platinum–NHC Cytotoxicity: Ligand Synthesis toward Dual-Mode Anticancer Complexes
N-Heterocyclic carbene (NHC) platinum complexes are pursued as anticancer agents acting outside cisplatin's DNA cross-linking mechanism. Guided by rational design, we target bis(NHC)Pt(II) dichlorides bearing redox-active ferrocenylmethyl arms intended to add ROS generation to platinum's protein-directed cytotoxicity. We report the convergent ligand synthesis: Mannich aminomethylation of ferrocene, quaternisation to the trimethylammonium iodide, Debus–Radziszewski assembly of 1-mesitylimidazole, and their coupling to 1-(ferrocenylmethyl)-3-mesitylimidazolium iodide, characterised by NMR spectroscopy. Carbene generation, platination, redox characterisation and biological evaluation are in progress.
Poster #34 | Rola Benammar | benammar.2@wright.edu
Research Advisor: Mark Rich, Ph.D.
Distinct types of muscle stiffness in myotonia congenita
Co-Authors: Rola Benammar, Shalyn Brown, Jared Edmonson, Mark Rich MD/PhD
Myotonia congenita (MC) is caused by loss-of-function mutations in the skeletal muscle chloride channel resulting in muscle stiffness due to impaired relaxation
Three types of myotonia were identified in mouse model of MC: spontaneous transient, stimulus-induced, and spontaneous sustained. Severity of each type of myotonia differs by temperature.
Our findings show that: the genetic model had more severe stimulus-induced myotonia than the pharmacological model at both temperatures; spontaneous sustained myotonia did not differ between wild-type and MC mice; spontaneous transient myotonia was greater in the pharmacological model, suggesting compensatory mechanisms in the genetic model.
Poster #2 | Supriya Bhukya | bhukya.11@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
The impact of Platelet-activating factor-receptor signaling and microvesicle particles in the cytotoxic efficacy of Aurora kinase inhibitors in Lung Cancer
Co-Authors: Supriya Bhukya, Nihal Annaparthi, Anita Thyagarajan, Ravi P. Sahu
Aurora kinases promote cancer growth, and its inhibition shows promising preclinical but limited clinical efficacy in lung cancer, suggesting counter-regulatory mechanism. We investigated the role of Platelet-activating factor-receptor (PAFR) and PAFR-dependent microvesicle particles (MVPs) in Aurora kinase inhibitors alisertib/barasertib response. Both drugs induced dose-dependent MVP release, which was blocked by PAFR and MVP inhibition, antioxidants, but not pancaspase inhibition, indicating PAFR-dependent oxidative stress response rather than apoptosis in this event. Add-back of drug-induced MVPs to naïve cells increased cell migration, similar to PAFR activation. These findings identify PAFR-MVP pathway as a counter-regulatory mechanism limiting Aurora kinase inhibitor efficacy in NSCLC.
Poster #57 | Lawrence Boateng | boateng.34@wright.edu
Research Advisor: Suzanne Lunsford, Ph.D.
Futures in chemistry- Empowering Young minds
Co-Authors: Suzanne Lunsford, Eric Fossum, Caitlin Wilson, Kwaku Nti Nyarko, Kinza Khan, and Sumitra Neupane
The “Futures in Chemistry” program introduces high school students to clean water issues through hands-on redox chemistry and heavy metal detection. Students visiting Wright State University learn to use a potentiostat and techniques including cyclic voltammetry and square wave anodic stripping voltammetry to identify metal ions in unknown water samples. The program promotes awareness of water quality, introduces careers in water quality management, and develops critical-thinking skills. Student learning is evaluated using pre- and post-tests, with educational gains assessed using the R.R. Hake method. In Fall 2026, the program served over 400 students, demonstrating its overall educational reach and impact.
Poster #69 | Makaya Brashares | brashares.3@wright.edu
Research Advisor: John Stireman, Ph.D.
Bristle flies of the Tropical Andes: Biodiversity, diversification, and mimicry
Co-Authors: John Stireman
Parasitic bristle flies (Tachinidae) are important in maintaining biodiversity in tropical ecosystems. Hedgehog flies (Epalpini) are a group of Tachinidae primarily found in the Andes that are characterized by reduced palpi and hairy bodies. They tend to be brightly colored and appear to comprise multiple mimicry complexes. However, Epalpini diversity remains unknown due to a lack of research. We aim to construct a phylogenetic framework for this lineage to understand their diversification and evolution, describe new species, and revise taxonomic keys. This will uncover hidden biodiversity and establish a baseline for conservation and further research.
Poster #55 | Kiyah Burroughs | burroughs.17@wright.edu
Research Advisor: Stacey Hundley, Ph.D.
Geologic Time and Evolution Education: utilizing interactive teaching methods to build scientific literacy
Many topics circulating throughout society involve scientific theories, such as evolution and climate, pushing for a proficiency in scientific literacy in everyday people. Interactive teaching methods are built around student involvement and engagement, allowing students to actively participate in their education to build critical thinking skills. Implementing interactive methods within biology lessons, such as the geologic time scale and vertebrate evolution, may allow non-science majors to implement critical thinking skills within the sciences, improving their scientific literacy and better equipping them for approaching science in their everyday lives. A pre-assessment and post-assessment comparison will be completed to analyze material retention.
Poster #61 | Eleanor Chase | chase.29@wright.edu
Research Advisor: Blake Stamps, Ph.D. (USAF)
Aerobic biodegradation of polyurethanes through the co-metabolism of volatile organic compounds.
Co-Authors: Victor Roman, Blake Stamps
High-performance polyurethane coatings protect critical infrastructure but pose severe disposal challenges, driving pollution and petrochemical reliance. Microbial valorization offers sustainable alternatives by degrading polymer waste into reusable monomers to support a circular bioeconomy. I hypothesize that specific microbes degrade polyurethanes via the co-metabolism of fuel-associated volatile organic compounds (VOCs). These VOCs may trigger enzymes that oxidize recalcitrant polyether polyurethanes, enabling further degradation. Here I am evaluating VOC associated fungal and bacterial strains in two phases: first monitoring enzyme expression with VOCs (toluene and hexane), then assessing polyurethane biodegradation with VOC exposure. Results will guide scalable polymer upcycling and infrastructure sustainability.
Poster #50 | Vaidehi Chaudhari | chaudhari.48@wright.edu
Research Advisor: Sarah Jackson, Ph.D.
Music & Attention: Examining Familiarity, Pitch & Task Performance.
Co-Authors: Sarah Jackson
Background music is commonly used while studying; however, it may have different effects on attention depending on the nature of the music. From previous literature, it has been observed that familiar background music affects attention and concentration during task performance, mood and level of arousal. The purpose of this literature review is to explore the research on the impact of music on students’ attention and cognitive task performances. Conclusions from this review will be used to propose an experimental research study to test the positive effect of music on task attention and performance.
Poster #12 | Akhila Chintala | chintala.31@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Efficacy of Repurposed Chlorpromazine in Glioblastoma
Co-Authors: Ravi P. Sahu
Glioblastoma is an aggressive primary brain tumor with rapid progression, poor prognosis, and limited treatment options. Epigenetic alterations contribute to tumor progression and therapeutic resistance, particularly temozolomide resistance associated with an unmethylated O6-methylguanine-DNA methyltransferase (MGMT) promoter. Drug repurposing such as chlorpromazine, an antipsychotic, has emerged as a potential therapy for glioblastoma. Preclinical studies suggest that chlorpromazine inhibits glioblastoma cell growth through multiple mechanisms, including downregulation of connexin-43, which contributes to chemotherapeutic resistance. A Phase II trial showed that chlorpromazine plus temozolomide prolonged progression-free survival in patients with unmethylated MGMT promoters. Further studies are needed to confirm efficacy and safety.
Poster #66 | Ryanne Cimatu | cimatu.2@wright.edu
Research Advisor: Katie Hossler, Ph.D.
Microplastics in Municipal Wastewater: Quantification, Fate, and Microbial Associations in West-Central Ohio Treatment Facilities
Co-Authors: Katie Hossler, Lucas Clark
Microplastics (MPs) are persistent contaminants that enter wastewater treatment plants (WWTPs) from domestic and industrial sources. MPs in the wastewater can be removed in WWTPs by transfer into sewage sludge; however, the biological mechanisms influencing this partitioning remain unclear. This study examines MPs in influent, aeration basins, and digested sludge at three West-Central Ohio WWTPs while characterizing activated-sludge microbial communities. Preliminary microscopy revealed differences in ciliate communities among facilities, particularly stalked and free-swimming ciliates. By integrating MP abundance, microbial community observations, and treatment parameters, this research investigates how biological treatment conditions influence MP retention and accumulation in wastewater sludge.
Poster #3 | Jack Clark | clark.762@wright.edu
Research Advisor: Jeffrey Travers, Ph.D.
Functional inhibitors of acid sphingomyelinase reduced microvesicle particle release in photosensitive models
Co-Authors: Avital Savin, Suvechha Bhandari, Christine M. Rapp, Karen M. Henkels, Kimaya Labde, Preethika Mandalapu, Young Jun Park, Isabel Tuckett, Jeffrey B. Travers
Photosensitivity disorders like xeroderma pigmentosum type A (XPA) cause adverse reactions to ultraviolet B (UVB) radiation. The pathway involved in photosensitivity immune response is not fully understood. We hypothesize that Platelet-activating factor activates acid sphingomyelinase (ASM) releasing microvesicle particles (MVPs) triggering systemic toxicity when exposed to UVB. Using murine and cellular models UVB exposure shows increased MVP release and systemic toxicity in photosensitive XPA knockout models. Treatment with functional inhibitors of ASM (FIASM) fluoxetine and amitriptyline before UVB exposure shows a decrease in MVP Release and inflammation. This suggests that FIASMs could be a novel therapy for photosensitive disorders.
Poster #62 | Justin Conley | conley.130@wright.edu
Research Advisor: Jeffrey Peters, Ph.D.
Speciation genomics of the Green-winged Teal (Anas crecca) complex.
Co-Authors: Jeffrey Peters
Uncovering the genomic signatures of divergence despite gene flow is fundamental to our understanding of the speciation process. The green-winged teal (Anas crecca) species complex shows signs of long-term semi-isolation with low levels of gene flow. In this study, we use DNA sequence data to investigate the genome for signatures of natural selection influencing speciation despite the presence of gene flow. Our data revealed three distinct populations and a narrow hybrid zone in Western Alaska. We also report signatures of selection with some regions of DNA showing elevated divergence and conflicting genetic relationships. These findings support “speciation with gene flow”.
Poster #4 | Hadassah S Davidson | davidson.150@wright.edu
Research Advisor: Adam Deardorff, Ph.D.
Neuromuscular Junction Function in Hyperkalemic Periodic Paralysis
Co-Authors: Arien K. McNeil, XueYong Wang, Mark M. Rich, Adam S. Deardorff
Hyperkalemic periodic paralysis (HyperPP) is classically attributed to impaired skeletal muscle excitability. However, our recent findings suggest that weakness in HyperPP may not be explained solely by muscle inexcitability. We investigated neuromuscular junction (NMJ) function in a mouse model of HyperPP using complementary physiological and structural approaches, including ex vivo muscle force recordings, intracellular muscle fiber recordings, and immunohistochemistry. These studies were designed to determine whether abnormalities in neuromuscular transmission or NMJ structure contribute to weakness in HyperPP. Across these analyses, we found no clear evidence of a structural or physiological deficit in NMJ function. Neuromuscular transmission remained intact by electrophysiologic and force-based measures, and immunohistochemical analysis did not reveal a consistent structural abnormality of the NMJ. Together, these findings suggest that weakness in HyperPP is unlikely to result from a primary defect of the neuromuscular junction and support further investigation of alternative mechanisms beyond skeletal muscle inexcitability.
Poster #35 | Meenu Devi | devi.40@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Efficacy and safety of chemoradiotherapy in small cell lung cancer
Co-Authors: Ravi P. Sahu
Limited-stage small cell lung cancer (SCLC) is a rapidly growing and aggressive disease, underscoring the importance of treatment strategies to optimize outcomes. Platinum-based chemotherapy regimens combined with radiotherapy is commonly used because of its effectiveness in improving tumor response and survival. Current studies have evaluated whether radiation dose modifications or advanced delivery methods, such as intensity-modulated radiation therapy (IMRT) and positron emission tomography-computed tomography (PET-CT), can further improve outcomes. The data demonstrate high response rates with concurrent chemoradiotherapy, with manageable side effects like esophagitis. These findings highlight concurrent chemoradiotherapy as an effective treatment approach for limited-stage SCLC.
Poster #17 | Widad El-Zein | el-zein.2@wright.edu
Research Advisor: Shulin Ju, Ph.D.
ALS-Linked MATR3 Causes Cell Size Enlargement in Budding Yeast
Co-Authors: Rahul Shah, Fawaz Gouse, Abigail Chumley, Elliott Hayden, Shuzhen Chen, Quan Zhong, Shulin Ju
Matrin-3 is a nuclear protein involved in RNA processing. Mutations in Matrin-3 have been linked to ALS, but the mechanisms underlying toxicity remain poorly understood. Disease-associated mutations have been shown to alter its localization and aggregation propensity. Using yeast, we have observed that expression of Matrin-3 recapitulates the pathological characteristics seen in ALS neurons. Interestingly, MATR3 expression also results in a significant increase in cell size. Cell size is tightly regulated and reflects coordination between growth, nutrient signaling, and cellular stress. In this study, we are exploring the role of ALS-associated Matrin-3 in disrupting growth-regulatory networks and stress pathways.
Poster #49 | Tim Fauley | fauley.2@wright.edu
Research Advisor: William Romine, Ph.D.
Effects of Fatigue on Multitasking Behavior and Performance
Fatigue affects your ability to multitask yet the physiological signatures while multitasking are poorly characterized. This DAGSI-funded, within-subjects study examines how fatigue affects multitasking behavior and performance using a custom-built Tetris task. Participants complete a Digit Span baseline and six Tetris tasks alternating between single-task play with dual-task blocks in which math problems appear simultaneously. Game events, math accuracy and reaction time, Paas cognitive-load and Samn-Perelli fatigue ratings, and physiological signals (heart rate, HRV, electrodermal activity) are collected. Preliminary results (if available) and the software pipeline are presented.
Poster #68 | Emily Gelske | gelske.2@wright.edu
Research Advisor: Don Cipollini, Ph.D.
Does size matter: How prairie size impacts pollinator diversity and services
Co-Authors: Don Cipollini
Pollinators are important not only for biodiversity, but also for human agriculture. Unfortunately, agriculture is one of many factors influencing biodiversity decline. I investigated how pollinator habitat size impacts pollinator services and diversity. Pollinator services were measured through the placement of pepper plants next to prairies of various sizes, using fruit growth as a proxy for pollinator services. Pollinator diversity was measured by identifying the pollinator communities at each prairie. Preliminary results show no evidence that prairie size impacts pollinator services or diversity. These results will help us understand how conservation practices can positively impact biodiversity and the agricultural industry.
Poster #31 | Syaron Ghising | ghising.3@wright.edu
Research Advisor: Courtney Sulentic, Ph.D.
Differential Effects of Perfluorooctanoic Acid (PFOA) on a Human B-cell line (CL-01) and its hs1.2 Variants
Co-Authors: Poorna Pranavi Komatineni, Sailaja Rachakonda, Courtney Sulentic
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant with potential health risks. Previous studies suggest that PFOA can suppress antibody response, but its direct effects on B cells and hs1.2 variants remain unclear. We evaluated PFOA (0.0125-0.1 µg/mL) effects on antibody secretion in CL-01 Wild Type (WT) and its variants 4D5 and 4E10 cells. Under stimulation, while the variants had nonsignificant IgG increase, CL-01 WT had increased IgA secretion at 0.025 µg/mL and an upward trend in IgG production. There were no significant effects without stimulation. These findings suggest that PFOA responses depend on the immunoglobulin isotype and hs1.2 genotype.
Poster #64 | Madeline Greene | greene.166@wright.edu
Research Advisor: Megan Rua, Ph.D.
Same species, different setting: Evaluating root-associated fungal pathogen communities across endemic and planted populations of Pinus radiata
Co-Authors: Sarah Addison, Steve A. Wakelin, Mariah Slaughter, Megan A. Rúa
Trees in naturally occurring populations experience long-term exposure to local pathogen communities, whereas human-planted trees may be separated from historically associated pathogens, experiencing a release from their enemies. However, whether this pattern holds for root-associated pathogen communities remains poorly understood. We quantified fungal pathogens of Pinus radiata across endemic and human-planted populations within its historical range. Endemic populations tended to support greater pathogen diversity than planted populations, with Shannon and Simpson diversity 28.9% and 11.5% higher, although neither was significant (p>0.05). These trends suggest planted trees may experience enemy release-like reductions in pathogen diversity even within their historically native ranges.
Poster #42 | Pooneh Hajmirza Mohammadi Kamalabadi | hajmirzamohammadikamalabadi.2@wright.edu
Research Advisor: Hongmei Ren, Ph.D.
Lipin1 Restoration Improves Muscle Pathology and Excitation–Contraction Coupling Ca²⁺ Handling in mdx Mice
Co-Authors: Scott Harper, Andrew Voss, Hongmei Ren
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin, leading to muscle degeneration, inflammation, and fibrosis. Lipin1, which regulates lipid metabolism and membrane homeostasis, is reduced in DMD patients and mdx mice. We restored Lipin1 in mdx mice by systemic MyoAAV3-Lipin1 delivery and by muscle-specific transgenic overexpression (mdx:lipin1^Tg/0^). MyoAAV3-Lipin1 reduced fibrosis and inflammation and improved muscle morphology. In fluo-4-loaded single fibers, mdx fibers showed a slower Ca²⁺ transient rate of rise, slower Ca²⁺ clearance, and fourfold more Ca²⁺ release failures than wild-type. Lipin1 overexpression restored both rate of rise and clearance. Lipin1 restoration improves dystrophic pathology and Ca²⁺ handling.
Poster #26 | Nimashi Herath | herath.4@wright.edu
Research Advisor: Kuppuswamy Arumugam, Ph.D.
Rational Design and Development of Novel Ferrocene-Based N-heterocyclic Carbene Gold Complexes as Potential Anticancer Agents
Co-Authors: Bawandeep Kaur, Kuppuswamy Arumugam
The anticancer potential of gold(I)-NHC complexes bearing sterically demanding ligands remains relatively unexplored. In this study, we rationally designed and synthesized a series of gold(I)-NHC complexes derived from a ferrocene-based NHC precursor. The synthetic work is currently in progress, with several intermediate compounds successfully prepared and preliminarily characterized by ¹H NMR spectroscopy. Further synthetic reactions are currently underway to obtain the desired target complexes and will be fully characterised using established organometallic methodologies, including ¹H and ¹³C NMR, IR, UV, and XRD. Redox behaviour will be evaluated using electroanalytical techniques, and anticancer activity will be evaluated using in vitro and in vivo biological assays.
Poster #44 | Caroline Hunt | hunt.175@wright.edu
Research Advisor: Steven Higgins, Ph.D.
Investigation of Calcium Fluoride Nucleation and Crystal Growth Chemistry Through Ion Selective Electrode Potentiometric Titrations: Thermodynamics vs Kinetics
Co-Authors: Steven Higgins, Avianna Gay, Marilyn Morupisi, Pusetso Mosesane
Classical nucleation theory (CNT) attributes crystal nucleation to statistical fluctuations in supersaturated solutions. More recently, prenucleation cluster (PNC) models have proposed that thermodynamically stable ion clusters form before bulk precipitation. However, previous work in our research group found no evidence that such clusters exist in equilibrium prior to nucleation. To investigate whether nucleation is governed by thermodynamics or kinetics, ion-selective electrode potentiometric titrations were used to study calcium fluoride crystallization. Results indicate that nucleation behavior observed with this technique may be kinetically controlled rather than thermodynamically controlled, suggesting the LaMer model is not universally applicable across all crystallization systems studied.
Poster #46 | Eric Jackson | jackson.379@wright.edu
Research Advisor: Allen Hunt, Ph.D.
Potential distribution, energy dissipation, and path entropy of of transport in disordered media
Conduction in disordered media is treated by percolation scaling results for the topology of the spanning network. When the individual channels exhibit varying local resistances, this treatment can be extended through by critical path analysis of an optimal network to which the scaling behavior again applies. This gives a distribution of path resistances which depends non-linearly on the system size. Determining the potential drops, or the flux, on these paths is complicated by the non-local dependence of these quantities. This work convolves the resistance distribution with itself under certain assumptions of the frequency and type of relevant intersections between paths based on a hierarchical model of the percolation backbone. The spatial dependence is then related to the energy dissipated and flow path entropy. This is postulated as the source of preferential streamflow seen in the the hydrological context.
Poster #19 | Mychaela Janzow | janzow.2@wright.edu
Research Advisor: Courtney Sulentic, Ph.D.
Investigating the role of ZFP36L1 and ZFP36L2 on host immune response and antiviral activity against RNA viruses
Co-Authors: Malabika Bhowmik, Tooba Momin, Mrigendra Rajput
CCCH-type zinc finger 36 family proteins (ZFP36) are RNA-binding proteins that regulate mRNA turnover. ZFP36 proteins also bind to viral RNA, controlling viral replication. ZFP36 proteins could also break down mRNA of pro-inflammatory cytokines, moderating virus-induced inflammation. We have found that the stable overexpression of ZFP36L1 significantly reduces rotavirus and norovirus titers, while knockdown of ZFP36L1 enhances viral titers and immune responses. Preliminary data shows overexpression of ZFP36L2 inhibits coronavirus replication, while knockdown of ZFP36L2 enhances viral replication. The aims of this study are to investigate the antiviral efficacy of ZFP36L1 and ZFP36L2 and their role in mitigating virus-induced inflammation
Poster #51 | Rylie Jeanneret | jeanneret.5@wright.edu
Research Advisor: Sarah Jackson, Ph.D.
Media Exposure and Traditional Gender Role Beliefs
Co-Authors: Sarah Jackson
Media content is everywhere; is exposure related to beliefs? This study examined how social media use and television exposure relate to impressions of men/women performing domestic tasks. We compared the correlations between TV exposure/social media use and evaluation of male or female photos from men and women in the sample (N = 134). For men, TV exposure/social media were positively correlated with evaluations of the female photo; these relationships were negative for female participants. Men also reported significantly higher traditional gender role beliefs than women. These findings suggest gender differences in how media exposure relates to gender role beliefs.
Poster #20 | Shamvabi Jha | jha.11@wright.edu
Research Advisor: Courtney Sulentic, Ph.D.
Effects of Non-Cytotoxic Hexavalent Chromium Exposure on Antibody Production in Human B Cells
Co-Authors: Courtney Sulentic
Environmental exposure to hexavalent chromium [Cr(VI)] may affect B-cell function and antibody production, but these effects remain poorly understood. We evaluated whether Cr(VI) alters antibody production at concentrations that do not cause substantial cytotoxicity. Human CL-01 WT B-cells were exposed to Cr(VI), and immunoglobulin secretion was measured following stimulation with CD40L and IL-4, with or without CD28. Preliminary analysis identified 0.01-0.1 µM Cr(VI) as non-cytotoxic. Cr(VI) minimally affected IgM and had no apparent effect on IgG or IgA following CD40L+IL-4 stimulation, while CD40L+IL-4+CD28 stimulation suggested reduced IgA secretion. Future studies will examine subchronic exposure.
Poster #21 | Vijayalakshmi Jogi | jogi.3@wright.edu
Research Advisor: Michael Kemp, Ph.D.
Development of a high-throughput assay for analyzing damaged cell-free DNA and identifying pharmacological modulators
Co-Authors: Michael G. Kemp
Cell-free DNA (cfDNA) supports noninvasive diagnosis and treatment monitoring, yet its DNA adduct content remains poorly studied. We developed a high-throughput, 96-well assay to detect UVB-induced, cisplatin, and benzo(a)pyrene diol epoxide adducts in cfDNA from human keratinocytes. DNA-repair protein depletion increased damaged cfDNA signals, while cascade inhibition reduced cfDNA release. Screening 2,320 FDA-approved drugs identified candidate compounds with increased cell viability and reduced cfDNA levels. This assay provides a platform for studying damaged cfDNA release and identifying pharmacological modulators, with potential applications in research and clinical samples.
Poster #52 | Krishna Joshi | joshi.161@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
The impact of psychological support on treatment outcomes in cancer patients
Co-Authors: Ravi Sahu
Cancer is a chronic illness associated with significant physical, emotional, and psychological challenges. Prolonged hospitalization, complex treatment regimens, and uncertainty about disease outcomes often contribute to anxiety, depression and emotional fatigue, negatively affecting quality of life. This study examines the impact of psychological support on cancer treatment outcomes in cancer patients, focusing on anxiety, treatment adherence, and daily functioning. Evidence from randomized trials, observational studies, and clinical experience indicates substantial psychological distress among patients and caregivers. These findings highlight that psychological interventions alleviate distress, provide emotional relief, improve well-being, enhance treatment adherence, strengthen social support, and promote comprehensive patient-centered cancer care.
Poster #5 | Kirtan Kachhadiya | kachhadiya.3@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Platelet-activating factor-receptor-dependent microvesicle particles modify the cytotoxic efficacy of signal transducer and activator of transcription 3 inhibitors in Non- Small Cell Lung Cancer
Co-Authors: Nihal Annaparthi, Krishna Joshi
Signal transducer and activator of transcription 3 (STAT3) is hyperactive in platelet-activating factor-receptor (PAFR)-driven non-small cell lung cancer (NSCLC). Microvesicle particles (MVPs) released in response to therapeutic agents are PAFR-dependent and associated with drug resistance. Despite promising preclinical efficacy of STAT3 inhibitors, the role of PAFR remains unclear. We hypothesized that PAFR-dependent MVPs attenuate STAT3 inhibitor efficacy. Data demonstrate that STAT3 inhibitor-induced MVP release is attenuated by PAFR inhibition. Add-back of these MVPs to untreated-naïve cells increased cell migration, similar to PAFR activation, suggesting that PAFR-dependent MVPs contribute to STAT3 inhibitor resistance, and represent a potential therapeutic target in NSCLC.
Poster #6 | Nishat Khalid | khalid.19@wright.edu
Research Advisor: Hongmei Ren, Ph.D.
Lipin1 Regulates Satellite Cell Function and Skeletal Muscle Regeneration in Dystrophic Muscle
Co-Authors: Hongmei Ren
Duchenne muscular dystrophy (DMD) is characterized by impaired skeletal muscle regeneration. Lipin1, a phosphatidic acid phosphatase, has been implicated in muscle regeneration, but its role in satellite cells remains unclear. We hypothesized that Lipin1 regulates satellite cell function and muscle regeneration. Restoration of lipin1 in mdx:lipin1 transgenic mice reduced muscle damage and was associated with decreased satellite cell abundance. Conversely, tamoxifen-inducible deletion of lipin1 in Pax7-positive satellite cells reduced satellite cell numbers and impaired muscle regeneration following BaCl₂-induced injury. These findings demonstrate that lipin1 contributes to satellite cell maintenance and effective skeletal muscle regeneration.
Poster #58 | Kinza Khan | khan.307@wright.edu
Research Advisor: Suzanne Lunsford, Ph.D.
Green Synthesized Nanoparticles to detect Antimony in bottled Water.
Co-Authors: Suzanne Lunsford
A green synthesis approach was employed for the preparation of cobalt nitrate hexahydrate as the precursor for nanoparticle formation with lettuce leaf extract. The synthesized nanoparticles were characterized by Fourier-transform infrared spectroscopy (FTIR) and UV–Visible spectroscopy, The resulting nanoparticles were immobilized onto a working carbon electrode surface that used Square Wave Anodic Stripping Voltammetry to detect heavy metals ions such as Antimony with the modified electrode. The developed approach has the potential to detect low amounts of Sb in common plastic bottles, thus offering a simple and environmentally friendly approach to trace-metal detection.
Poster #54 | Cohen Kohorst | kohorst.6@wright.edu
Research Advisor: Stacey Hundley, Ph.D.
Evaluating the Impact of Bioethics Education on Undergraduate Ethical Perspectives
Bioethical issues are increasingly important in healthcare, research, scientific fields, and public policy, which require critical thinking and ethical reasoning. This study will evaluate whether participation in an undergraduate bioethics course leads to measurable shifts in students’ perspectives on selected ethical issues. Undergraduate students will voluntarily complete pre- and post-course surveys containing demographic, Likert-scale, multiple-choice, and free-response questions that address topics such as patient autonomy, organ allocation, end-of-life decisions, and much more. Pre- and post-course responses will be compared using frequencies, percentages, and statistical analyses. It is expected that students will demonstrate increased awareness and consideration of bioethical principles.
Poster #1 | Ajay Kumar | ajay.kumar@wright.edu
Research Advisor: Madhavi Kadakia, Ph.D.
FBW7 and TIP60 Differentially Regulate MDM2 in Squamous Cell Carcinoma
Co-Authors: Mackinzie A. Clegg, and Madhavi P. Kadakia
MDM2 is a well-known E3 ubiquitin ligase that negatively regulates p53. Although MDM2 is regulated by multiple pathways, its regulation in squamous cell carcinoma (SCC) remains incompletely understood. Here, we studied how FBW7 and TIP60 regulate MDM2 in SCC. FBW7 overexpression reduced MDM2 levels, whereas its depletion increased it, with only a modest increase in MDM2 half-life. In contrast, TIP60 depletion reduced MDM2 protein and mRNA levels, whereas TIP60 overexpression increased MDM2 promoter activity and protein levels. The increase in MDM2 protein was particularly evident in nuclear and chromatin fractions, without an effect on protein stability. Together, these findings suggest distinct mechanisms by which FBW7 and TIP60 regulate MDM2 in SCC.
Poster #11 | Zachary Kuntz | zac.kuntz@wright.edu
Research Advisor: Hongmei Ren, Ph.D.
Lipin1 restoration suppresses cardiomyopathy progression in Duchenne Muscular Dystrophy
Co-Authors: John Kamau, Hongmei Ren
Duchenne muscular dystrophy (DMD) is a progressive X-linked disease characterized by skeletal and cardiac muscle degeneration, inflammation, fibrosis, and premature mortality. Loss of dystrophin compromises sarcolemmal stability, contributing to progressive muscle injury and pathological remodeling. Lipin1, a phosphatidic acid phosphatase with roles in membrane lipid metabolism and membrane integrity, is reduced in dystrophic muscle. To investigate whether restoring lipin1 protects against DMD-associated cardiomyopathy, we analyzed cardiac tissue from 6-month-old D2-mdx:lipin1Tg/0 mice. Lipin1 restoration significantly reduced inflammation and improved structural protein expression and localization. These findings support lipin1 as a potential therapeutic target for limiting DMD-associated cardiac pathology.
Poster #13 | Kimaya Labde | labde.2@wright.edu
Research Advisor: Jeffery Travers, Ph.D.
Acid Sphingomyelinase dependent MVP release following thermal burn injury and photodynamic therapy.
Co-Authors: Preethika Mandalapu, Christine M. Rapp, Karen M. Henkels, Wenfeng zhang, Suvechha Bhandari, Avital Savin, Jeffery B. Travers .
Photodynamic therapy (PDT) and thermal burn injury (TBI) induce cellular stress which is followed by release of microvesicle particles (MVPs). Exact underlying mechanism behind MVP release is unknown. We hypothesize that enzyme acid sphingomyelinase (ASM) translocation to plasma membranes and resultant ceramide release is causing MVP shedding. HaCaT wild type and HaCaTASMKO keratinocytes were created and expression of ASM assessed using western blotting and RTq-PCR. PDT- and TBI-induced expected MVP responses in HaCaTWT cells, but cells with absence of ASM (HaCaTASMKO) demonstrated less release of MVPS, suggesting that ASM is required for these stimuli to cause MVP shedding.
Poster #63 | Ellen Lee | lee.413@wright.edu
Research Advisor: Jeffrey Peters, Ph.D.
Preliminary results of Avian Influenza screening of Passerine birds from Poland
Avian Influenza (AI), including highly pathogenic strains, continues to expand its geographic range and host diversity, and therefore, surveillance of wild bird populations is necessary for early detection and risk assessment. To assess the incidence and diversity of AI in Poland, we collected fecal samples from approximately 500 migratory birds during early Fall migration in 2024 and 2026. These samples will be screened for AI using Polymerase Chain Reaction. Here, we present some preliminary results of positive vs negative infections of AI grouped by migratory bird status.
Poster #27 | Puja Luitel | luitel.11@wright.edu
Research Advisor: Kuppuswamy Arumugam, Ph.D.
Redox-Active Ferrocenyl Bis(NHC) Nickel(II) Anticancer Agents
Metal N-heterocyclic carbene (NHC) complexes are versatile organometallic compounds whose biological activity can be precisely tuned through ligand design. N-heterocyclic carbenes bind transition metal through strong σ-donation, producing metal complexes that resist hydrolysis under physiological conditions. Anticancer behaviour is governed largely by the metal center, but can also be modified by redox-active groups appended to the ring nitrogen. The current project seeks to understand how a redox-active nickel (II) center, that are coupled with ferrocenyl side groups to undergo reversible one –electron oxidation, affects reactive oxygen species generation and cytotoxicity in bis(carbene)nickel (II) systems.
Poster #28 | Maggie Mann | mann.110@wright.edu
Research Advisor: Kanishka Sikligar, Ph.D.
DNA Dendrons: Programmable Carriers for Protein Therapeutics
Co-Authors: Kanishka Sikligar
Protein therapeutics offer powerful strategies to target, replace, or regulate disease pathways, yet their application is largely limited to extracellular and membrane-associated targets. Efficient intracellular delivery remains a major challenge. Strategies such as cell-penetrating peptides and protein-based spherical nucleic acids (proSNAs), in which proteins are densely functionalized with DNA, can enhance cellular uptake while preserving protein function. Here, site-specific modification and click chemistry will be leveraged to construct DNA-dendron–protein conjugates as programmable delivery platforms. This approach will be explored for targeted delivery of therapeutic proteins to address aggressive cancers, including castration-resistant prostate cancer (CRPC).
Poster #18 | Megha Ann Manoj | manoj.10@wright.edu
Research Advisor: Shulin Ju, Ph.D.
Stress Granule Proteins Rescue ALS-Associated FUS toxicity in Yeast
Co-Authors: Widad El-Zein, Elliot Hayden, Shuzhen Chen, Quan Zhong, Shulin Ju
Fused in Sarcoma (FUS) is an ALS-associated RNA-binding protein that when mutated, mislocalizes and forms aggregates in neuronal cytoplasm, and leads to cell death. It was found that the FUS aggregates colocalize with cellular stress response structures called Stress Granules. We hypothesize that FUS imposes stress on cells and impairs the stress response function of the Stress Granules. Using genetic screening in yeast, we identified 15 Stress Granule-related genes that suppress FUS toxicity. We aim to investigate the relationship between FUS and Stress Granules and how these suppressors rescue the cells using yeast as a model organism.
Poster #59 | Avianna Gay | mcdaniel.63@wright.edu
Research Advisor: Steven Higgins, Ph.D.
Drop wise Fluoride Delivery Reveals Hidden Kinetics in Potentiometric Precipitation Titrations: Rethinking Pre nucleation Signatures in CaF₂ Systems
Potentiometric precipitation titrations typically assume fully mixed titrant delivery, yet a deviation from our standard method—adding NaF dropwise above the solution rather than through a submerged tube—created discrete, time resolved perturbations in the F ISE signal. These regularly spaced pulses enabled calculation of dC/dt between drops, revealing a previously hidden transition in the fluoride concentration profile. Negative slopes indicated sustained F⁻ consumption, while positive slopes reflected release. A narrow inflection window marked the onset of autocatalytic CaF₂ growth, a mechanistic feature completely masked under conventional continuous flow or submerged tip titration protocols.
Poster #22 | Arian McNeil | mcneil.19@wright.edu
Research Advisor: David Ladle, Ph.D.
Ranolazine Attenuates C-Fiber Hyperexcitability More Effectively Than Suzetrigine
Co-Authors: Adam S. Deardorff, Mark M. Rich, David R. Ladle
Peripheral nerve hyperexcitability contributes to neuropathic pain. We compared ranolazine and suzetrigine in an ex vivo mouse sciatic nerve compression model. Compound action potentials were recorded before, during, and after compression. Compression blocked A-fiber conduction, while C-fiber responses increased over time at 30°C. Only 2/10 nerves treated with 80 µM ranolazine showed ≥30% increases in C-fiber RMS, compared with 9/10 receiving 2.1 µM suzetrigine. Suzetrigine reduced A-fiber amplitude, whereas ranolazine produced no significant change. These findings support further investigation of ranolazine for neuropathic pain and motivate a planned clinical study assessing its potential efficacy in affected patients.
Poster #14 | Alissa Meeks | meeks.43@wright.edu
Research Advisor: Dan Krane, Ph.D.
Mapping Forensic DNA Practice: A database of SOPs
Co-Authors: Dan Krane, Nathaniel Adams, Rediet Abebe
Forensic DNA laboratories rely on standard operating procedures (SOPs) and internal validation studies to define how DNA evidence is analyzed and interpreted, yet these documents are dispersed across hundreds of laboratories. This project is developing a structured database linking U.S. forensic laboratories to their SOPs and internal validation materials and compiling those documents into a searchable collection. By making these materials easier to compare, the project will provide a foundation for studying variation in forensic DNA practice, including how laboratories approach complex DNA mixtures and how those approaches change over time — and where greater attention to scientific rigor might strengthen validation and interpretation practices.Poster #7 |
Shahd Mohamed | mohamed.74@wright.edu
Research Advisor: Weiwen Long, Ph.D.
FBXL16 Depletion Activates p38-Mediated Apoptosis in Lung and Breast Cancer Cells
Co-Authors: Madison Alexander, Marion Morel
Lung cancer and breast cancer account for over one-fourth of global cancer deaths. The F-box protein FBXL16 is highly expressed in various cancers and supports tumor cell survival. Our lab has found that FBXL16 upregulates DUSP4, a phosphatase that dephosphorylates and suppresses the stress kinase p38. Since p38 promotes cell death, we hypothesize that FBXL16 depletion enhances p38 phosphorylation and activity, inducing apoptosis and suppressing cell growth. Indeed, either transient silencing or stable depletion of FBXL16 increased p38 phosphorylation, elevated the levels of pro-apoptotic markers, and reduced cell growth in both lung cancer and breast cancer cells.
Poster #47 | Sonali Mohan | mohan.24@wright.edu
Research Advisor: Allen Hunt, Ph.D.
Storm Interval Scale Study of Run-off for Dry Catchments with Threshold Soil Water Content
Co-Authors: Allen Hunt, Jasper Vrugt
The time scale dependence of streamflow response to precipitation is a complex problem in hydrology that links annual water balance studies, surface and subsurface flow paths, and plant behavior. Storage is not only the dominant driver of recession flow, when precipitation and evapotranspiration can be negligible, but also a major contributor to streamflow elasticity at seasonal and shorter time periods during the change from the dry season to the wet especially, in dry catchments like dry tropical forests. In dry regions, a rather sharp increase in streamflow past threshold storage has been observed. Thus, understanding the streamflow (Q) - precipitation (P) relationship in hydrology is key for managing water systems in regions with distinct seasons and frequent droughts. A basis for understanding the Q-P relationship is proposed in an ecological optimality hypothesis of the water balance which determines how precipitation divides into runoff and evapotranspiration in such a way as to maximize vegetation productivity. Empirical data confirms relevance of the optimality hypothesis to streamflow prediction. Optimality succeeds as long as changes in storage can be neglected over the time scale considered, at least in the catchments investigated where the same optimality condition on evapotranspiration yielded verified predictions of streamflow at seasonal and storm interval time scales, although with variable scatter and, in some cases, bias. The catchments considered are in Oman, Brazil, and the mountains of southwestern Mexico, for which sufficient data were compiled to test the above hydrological viewpoints. While extending this predictive model to other regions requires targeted, high-quality data collection, the framework provides a powerful, validated blueprint for global watershed management.
Poster #29 | Darwin Muñoz | munozcabrera.3@wright.edu
Research Advisor: Kanishka Sikligar, Ph.D.
Mitochondria-Targeted Ionic Liquids
Co-Authors: Kanishka Sikligar
Mitochondria regulate cellular energy production, metabolism, and signaling, making them compelling targets for cancer therapy. However, selective mitochondrial drug delivery remains challenging. Our group aims to investigate ionic liquids (ILs) as tunable platforms for mitochondrial targeting and drug delivery. By systematically modifying their cationic and anionic components, we will develop ILs with optimized physicochemical properties, cellular uptake, and mitochondrial selectivity. Positively charged IL analogues will be designed to exploit the mitochondrial membrane potential, promote mitochondrial accumulation, and perturb membrane integrity. These platforms will be evaluated for their ability to trigger mitochondrial dysfunction and apoptosis in drug-resistant tumor models.
Poster #67 | Angie Muse | muse.21@wright.edu
Research Advisor: Katie Hossler, Ph.D.
Crayfish-mediated improvement of stream and riparian health following removal of Lonicera maackii
Co-Authors: Katie Hossler
Lonicera maackii (amur honeysuckle) is an invasive species of Ohio that has detrimental impacts on riparian areas. Establishment of L. maackii induces physical changes that reduces diversity and degrades water quality and soil health. Removal of the species can be physically demanding and, may still require subsequent restoration which can be costly. This is where native crayfish species may be able to help. Crayfish are omnivores and are prominent keystone species when it comes to top-down control. This study will assess whether the presence of native crayfish impacts soil health, water chemistry, and algal growth following removal of L. maackii.
Poster #60 | Kwaku Nti Nyarko | nyarko.12@wright.edu
Research Advisor: Suzanne Lunsford, Ph.D.
Determination of detect heavy metals in water using a green synthesized silver nanoparticles modified glassy carbon working electrode.
Co-Authors: Suzanne Lunsford
The contamination of water sources by heavy metals such as lead (Pb²⁺), cadmium (Cd²⁺), Mercury (Hg2+) and Antimony (Sb3+) poses severe health risks to humans and the environment in general. There is an urgent need for development of sensitive, rapid, and cost-effective analytical methods for their detection utilizing electrochemistry techniques. Electrochemical sensors based on nanoparticle surface modified electrodes have become known as a promising solution. This study shows the performance of green synthesized silver nanoparticles (AgNPs) modified working glassy carbon electrode in determining trace of heavy metals in water bodies using square wave anodic stripping voltammetry (SWASV).
Poster #53 | Emma Orsi | orsi.4@wright.edu
Research Advisor: Dragana Claflin, Ph.D.
Preference Choice and Memory Testing in Eisenia fetida
Studies on invertebrates provide evidence that organisms with simple nervous systems can retain and retrieve information similarly to complex animals. The present experiments investigate memory retention in Eisenia fetida, a red-wiggler earthworm, by examining responses to odors during repeated exposures. Experiment one is a preference test between banana and orange and experiment two is a spatial memory test. Findings suggest that worms tend to choose banana over orange as indicated by a higher approach frequency and they demonstrate clear memory for the location of banana. These findings provide support for the use of simple organisms to investigate learning and memory.
Poster #41 | Parth Panara | panara.2@wright.edu
Research Advisor: Kuppuswamy Arumugam, Ph.D.
Redox-Active Gold Complexes as Next-Generation Cancer Therapeutics
Gold(I)–N-heterocyclic carbene (Au(I)–NHC) complexes show promising anticancer activity through thioredoxin reductase (TrxR) inhibition and disruption of cellular redox balance. This project focuses on the synthesis and characterization of redox-active Au(I)–NHC complexes incorporating naphthoquinone-derived ligands and targeting groups. Their redox properties, TrxR inhibition, reactive oxygen species generation, and cytotoxicity will be investigated. Click-chemistry-based bioconjugation will be explored to improve cellular uptake and cancer-cell selectivity. This work aims to establish structure–activity relationships for the development of next-generation gold-based anticancer therapeutics.
Poster #8 | Dhara Patel | patel.2045@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
Role of platelet-activating factor-receptor signaling in Dichloroacetate efficacy in Lung cancer
Co-Authors: Anita Thyagarajan, Ravi P. Sahu
Cancer cells rely on glycolysis for energy production and growth, and dichloroacetate (DCA), an antiglycolytic agent, has been shown to shift metabolism from glycolysis to mitochondrial oxidative phosphorylation, promoting cell death. However, oncogenic pathways can counteract DCA effects. Platelet-activating factor-receptor (PAFR) pathway supports cancer growth, including non-small cell lung cancer (NSCLC). This study investigates the impact of PAFR signaling on DCA efficacy. DCA exhibited dose-dependent inhibition of NSCLC survival and migration. While PAFR activation attenuated, PAFR antagonism enhanced, DCA-mediated anti-migratory and anti-clonogenic effects. These findings identify PAFR as a potential therapeutic target to augment DCA efficacy in NSCLC.
Poster #36 | Matthew Pickrell | pickrell.7@wright.edu
Research Advisor: Juliusz Kozak, Ph.D.
Effects of extracellular Mg2+ and Ca2+ on cell diameter, proliferation and cytotoxicity
Co-Authors: Soumya Bajpai
It is well known that maintenance and propagation of mammalian cell lines in vitro requires divalent metal ions Ca2+ and Mg2+. Thus, cell culture media formulations normally contain millimolar quantities of both ions, similar to their levels in the blood. The exact pathways for their entry into cells, however, have not been established. We hypothesized that endogenous Orai1 and TRPM7 channels are responsible for influx of Ca2+ and Mg2+. We have used several approaches to measure HEK293 cell proliferation under varying Mg2+. In order to study TRPM7 in isolation, we used Orai1 knockout HEK293 cells that were depleted of Mg2+.
Poster #30 | Sima Rai | rai.69@wright.edu
Research Advisor: Kuppuswamy Arumugam, Ph.D.
Ferrocene–NHC Palladium(II) Hybrids: Design, Synthesis, and Anticancer Potential
Current chemotherapy is limited by multidrug resistance and severe systemic toxicity, highlighting the need for innovative metal-based therapeutics. This study presents the synthesis and biological evaluation of novel ferrocene-functionalized N-heterocyclic carbene palladium(II) complexes as potential anticancer agents. Incorporation of ferrocene provides redox activity and may enhance cellular uptake, while the NHC–Pd framework offers structural stability. The complexes are designed to exert dual anticancer effects through inhibition of critical cellular enzymes and reactive oxygen species generation, promoting apoptosis. Spectroscopic and computational studies investigate their structures and structure–activity relationships. These ferrocene–Pd hybrids represent a promising approach toward effective metallodrugs with improved bioavailability and potentially reduced systemic toxicity.
Poster #15 | Yasmeen Razi | razi.2@wright.edu
Research Advisor: Quan Zhong, Ph.D.
Studying the Protein Interactions of α-synuclein using a modified Yeast Two-Hybrid Approach
Co-Authors: Ishita Haider, Quan Zhong
α-Synuclein, encoded by the SNCA gene, is implicated in Parkinson’s Disease (PD) and Lewy Body Dementia (LBD) through its misfolding, aggregation, and the formation of Lewy bodies. The factors driving its pathological transition remain unclear, and understanding protein-protein interactions is key to elucidating disease mechanisms. This study uses C-terminally tagged α-synuclein in the Yeast Two-Hybrid (Y2H) assay to preserve its native structure and to compare the interactions between wild-type and mutant proteins. Characterizing differences in their interaction networks may help clarify how changes in specific binding partners promote Lewy body formation and contribute to the development of PD and LBD.
Poster #16 | Isabel Reyna | reyna.7@wright.edu
Research Advisor: Quan Zhong, Ph.D.
Identifying Factors That Influence Ypt1-Mediated Suppression of α-Synuclein Toxicity
Co-Authors: Ishita Haider, Breonna Gillespie, Sonu Yadav, Shulin Ju, Quan Zhong
Alpha-synuclein (α-syn) is a small, lipid-binding protein genetically and pathologically linked to Parkinson’s disease. The Rab GTPase Ypt1 suppresses α-syn toxicity and is involved in autophagy and membrane trafficking. We have identified two Ypt1 point mutants that fail to suppress α-syn toxicity, suggesting that specific Ypt1 functions may be important for its protective activity. To investigate how Ypt1 suppresses α-syn toxicity, we aim to test physical interactions of Ypt1 (wild-type and the point mutants) with autophagy and membrane trafficking proteins. These studies will help identify Ypt1 functions that influence α-syn toxicity.
Poster #39 | Rebecca Riley | riley.214@wright.edu
Research Advisor: Sherif Elbasiouny, Ph.D.
Intrinsic motoneuron properties in controls of a new C9orf72 animal model of ALS
Co-Authors: Andrew Deutsch
Amyotrophic lateral sclerosis (ALS) is a disease that causes the progressive death of motoneurons (MNs). Mutations of the C9orf72 gene are the most common mutations found in familial and sporadic ALS. An established mouse model based on an FVB/NJ background has proven to be problematic due to wildtype littermates suffering seizures and motor deficits. We have developed a new C9orf72 mouse model on the C57BL/6 background to address this limitation. In this poster, we compare intrinsic MN properties between the two wildtype groups using electrophysiology. Preliminary data shows that the new model shows no signs of seizures or motor deficits.
Poster #37 | Cooper Roberts | roberts.531@wright.edu
Research Advisor: Mark Rich, Ph.D.
Effects of Chronic Sodium Channel Blockade on Muscle Weakness in Hyperkalemic Periodic Paralysis
Co-Authors: Mark M. Rich
Hyperkalemic periodic paralysis (HyperKPP) is caused by abnormal sodium channel activity resulting in persistent sodium influx current, myotonia, episodic weakness, and chronic muscle weakness. We investigated whether chronic sodium channel blockade improves muscle function in HyperKPP mice. Mice were treated with ranolazine for one month, followed by ex vivo force recordings of extensor digitorum longus muscles. Ranolazine-treated HyperKPP muscles showed increased force compared with untreated HyperKPP muscles. These preliminary findings suggest sodium channel blockade may improve muscle function in HyperKPP and support further investigation with larger sample sizes. More experimentation is needed to reach statistical significance.
Poster #56 | Riley Rush | rush.45@wright.edu
Research Advisor: Suzanne Lunsford, Ph.D.
Codetection of Arsenic and Selenium with Polyaniline Modified Electrodes
Co-Authors: Suzanne Lunsford
Arsenic and selenium are toxic to humans in high enough concentrations. As such, monitoring these heavy metals is important for public safety. These metals can be tested with electrochemical methods, but there is a chance of interference when detecting metals simultaneously. Polyaniline (PANI) added to electrode surfaces could optimize detection of arsenic and selenium and enhance the detection of both metals in a water sample without interference issues. PANI was grown using electrochemical methods as well as in solution with copper nanoparticles. The detection of these metals will be illustrated by Square Wave Anodic Stripping Voltammetry without needing prior separation.
Poster #23 | Diksha Saini | saini.71@wright.edu
Research Advisor: Clintoria Williams, Ph.D.
Does zinc deficiency cause renal inflammation?
Co-Authors: Hannah E. Morgan, Khanzada Hasrat, Clintoria R. Williams
Background: 87% of patients with chronic kidney disease CKD are zinc deficient, an unrecognized nutritional deficiency. However, the role of ZnD in CKD progression remains unexplored.
Objective: Since CKD is driven by inflammation, this study determined whether ZnD causes kidney damage and renal inflammation. To this end, mice were fed a zinc adequate (ZnA) or ZnD diet and examined for kidney damage and inflammation.
Results: Compared to ZnA, ZnD mice had higher urinary inflammatory markers, increased macrophage infiltration and glomerular damage.
Conclusion: These findings indicate that ZnD-induced renal damage is accompanied by inflammation, which may drive kidney damage in CKD.
Poster #9 | Mansi Sharma | sharma.345@wright.edu
Research Advisor: Ravi Sahu, Ph.D.
The role of the platelet-activating factor-receptor pathway in the cytotoxic response to epidermal growth factor receptor inhibitor in non-small cell lung cancer
Co-Authors: Anita Thyagarajan, Ravi P. Sahu
Non-small cell lung cancer (NSCLC) is a leading cause of lung cancer-related mortality worldwide, with epidermal growth factor receptor (EGFR) mutations contributing to therapeutic resistance. This study investigates the role of PAFR signaling in the efficacy of the EGFR inhibitor, Osimertinib using EGFR-wild type and EGFR-mutated cell lines. Osimertinib exhibited dose-and time-dependent inhibition of NSCLC survival and migration. PAFR agonism attenuated, whereas PAFR antagonism enhanced, osimertinib-mediated anti-migratory and anti-clonogenic effects, with more pronounced effects in EGFR-mutated cells. These findings identify PAFR signaling as a potential target to enhance osimertinib responses in NSCLC.
Poster #40 | Hiya D. Shukla | shukla.23@wright.edu
Research Advisor: Eric Fossum, Ph.D.
Enabling PEI gene vector tracking by covalent attachment of a blue-light emitting, benzoxazole-based chromophore
Co-Authors: Eric Fossum
Gene therapy is a widely used approach for treating both acquired and inherited diseases. Gaining insight into intracellular gene vector behavior can provide a better understanding of the factors contributing to the gene delivery process. Introducing vector trackability could therefore be a useful tool for evaluating gene delivery systems. Our work aims to synthesize a highly efficient benzoxazole-based blue-chromophore for covalent attachment to a non-viral vector, polyethyleneimine. The chromophore allows fluorescence trackability while maintaining gene-delivery functionality. Fluorescence microscopy can be used to visualize the vector during transfection studies. Ultimately, this work aims to develop a trackable gene delivery platform.
Poster #70 | Jamie Stopczynski | stopczynski.2@wright.edu
Research Advisor: Volker Bahn, Ph.D.
Pinpointing Cryptic Species: Acoustic Localization of Secretive Marsh Birds
Secretive marsh birds are a declining group of wetland-dependent species almost exclusively studied using vocalization data. Single-location surveys are unable to estimate spatial density, but acoustic array localization may provide valuable population data. In this study, I aim to test precision of localization technology and to determine marsh bird abundance and density within arrays. To accomplish this, I deployed synchronized AudioMoth recorders in an established marsh and will localize bird vocalizations to map individuals over multiple months. Obtaining relative abundance/densities of birds within my arrays will demonstrate potential for long-term, non-invasive monitoring of secretive species populations using autonomous recording units.
Poster #38 | Sushaen Prabhala | sushaen.prabhala@wright.edu
Research Advisor: Clintoria Williams, Ph.D
Investigating Tacrolimus-Induced Kidney Dysfunction and Irreversible Kidney Damage via Dietary Administration
Co-Authors: Kylie E. Bachmann, Tara Wenegieme-Yesomi, Clintoria R. Williams
Tacrolimus is a commonly used immunosuppressive drug taken by 90% of kidney transplant recipients to prevent transplant rejection but can cause damage in the long-term. Currently, researchers investigating in animal models use injections to administer tacrolimus, but this causes stress to the animals, confounding results. This study evaluated a novel tacrolimus medicated diet, developed as a clinically relevant and less stressful alternative. Male, wild-type mice received either standard chow or the tacrolimus medicated diet for 4 weeks. Findings suggest that the medicated diet successfully induces tacrolimus-induced kidney damage, potentially offering a safer and less stressful tacrolimus-administration model for animal investigations.
Poster #10 | Chandler VanBuskirk | vanbuskirk.13@wright.edu
Research Advisor: Weiwen Long, Ph.D.
The F-Box Proteins FBXL16 and FBXO45 co-regulate Estrogen-Receptor-Alpha in ERα+ Breast Cancer and Mediate response to Fulvestrant treatment
Co-Authors: Abigail J. McCarty, Krushangi Shah, Weiwen Long
In estrogen receptor-alpha positive (ERα+) breast cancer, ERα responds to estrogen, and signals cell proliferation and tumor growth. The E3 ubiquitin ligases, FBXO45 and FBXL16 may provide insight to ERα stability in breast cancer. FBXO45 acts as a regulator of ERα stability, whereas FBXL16 helps stabilize ERα, acting as an E3 ligase for FBXO45. Using ERα+ cell lines MCF-7 and T47D, shRNA depletion of FBXO45 and FBXL16 had opposing roles on the stability of ERα. When treated with the selective estrogen receptor degrader (SERD) fulvestrant, cells showed an increase in FBXO45, providing insight to a mechanism of fulvestrant-mediated ERα degradation.
Poster #65 | Katie Weddle | weddle.8@wright.edu
Research Advisor: Jeffrey Peters, Ph.D.
Lights Out Dayton- monitoring avian window strikes
Windows pose a great risk to migratory birds, especially when artificial light at night (ALAN) attracts migrating birds into cities where they strike windows. Several Ohio cities monitor these window collisions, but how often birds strike windows in Dayton is not known. Surveys were completed in May 2026 by searching for deceased and injured birds. Thirteen deceased migratory birds were encountered, and three injured birds were transported to Brukner Nature Center for rehab. These birds struck buildings with high surface areas of windows. Turning off lights at night during migration and placing stickers on windows can reduce avian window strikes.
Poster #24 | Sonu Yadav | yadav.60@wright.edu
Research Advisor: Quan Zhong, Ph.D.
Rab GTPase-mediated membrane remodeling and α-synuclein toxicity in yeast
Co-Authors: Ishita Haider, Breonna Gillespie, Shulin Ju, Quan Zhong
Abnormal α-synuclein (α-syn) accumulation and dysfunction of the endolysosomal and autophagy pathways are central features of Parkinson’s disease. Using yeast models of α-synuclein toxicity, we identified Rab proteins and Rab-associated factors that suppress or enhance α-syn toxicity. We are investigating how these factors regulate membrane trafficking and autophagy to understand their effects on α-syn toxicity. We established fluorescent protein markers of the ER, Golgi, endosomes, and autophagosomes to assess these pathways. We hypothesize that Rab-dependent membrane trafficking and autophagy regulate the cellular response to α-synuclein. Together, this work will help define the role of Rab-dependent membrane remodeling in α-synuclein toxicity.
Event Contact
Steven Higgins, Ph.D.
steven.higgins@wright.edu