Dr. Michael Leffak's laboratory published in Nature Chemical Biology that probing trinucleotide repeat structures using engineered zinc-finger nucleases provides evidence that DNA hairpins form in vivo and are linked to replication-dependent genomic instability. Instability of (CTG)-(CAG) repeats in microsatellite DNA has been linked to numerous neurological diseases.
Dr. Julian G. Cambronero's laboratory has discovered that the enzyme phospholipase D2 (PLD2) binds directly to the small GTPase Rac2. This discovery, published in the Proceedings of the National Academy of Sciences represents the first report of a phospholipase enzyme harboring guanine nucleotide exchange (GEF) activity. Given that several human tumors exhibit elevated PLD2 levels this work suggest that this elevation may impact Rac2...
Dhawal Oswal (Dr. Hostetler's lab) was awarded an American Society of Biochemistry and Molecular Biology travel award to attend the Experimental Biology meeting in San Diego, April 20-25, 2012, where he presented his work on "Fatty acids and their thioester derivatives as ligands for human PPARalpha."
Madhumitha Balanarasimha, Hostetler lab, was awarded an ASBMB (American Society of Biochemistry and Molecular Biology) travel award to attend the Experimental Biology meeting in Washington, D.C., April 8-13 where shepresented her work on the demonstration of interaction of full-length PPARa and LXRa.
Sam Kantonen, an undergrad student at Dr. Julian Cambronero’s lab, was selected to present a paper at the National Conference on Undergraduate Research (NCUR) 2011 at Ithaca College, New York, April 1, 2011. The paper, “Wiskott-Aldrich Syndrome Protein Interacts with Phospholipase D2 through Growth Factor Receptor-Bound Protein 2,” allowed Sam to present the results of his research at a national venue. The NCUR,...
Dr. Lawrence Prochaska was appointed to the editorial board as a review editor of the journal Frontiers in Mitochondrial Physiology in November.
Dr. Julian Gomez-Cambronero was invited to serve as a member of the Innate Immunity and Inflammation Study Section (National Institutes of Health) for a four-year term beginning in late 2009
Kevin Kelley, M.D./Ph.D., student in Dr. Berberich's lab was awarded the 2010 Academy of Medicine Outstanding Student Research Award. Kevin successfully defended his thesis in May and will be returning to his third year of medical school later this summer.
Madhu Mahankali received the Biomedical Sciences Ph.D. program's Graduate Student Excellence Award for the 2009-10 academic year. Madhu is completing her Ph.D. thesis in Dr. Julian Gomez-Cambronero's laboratory studying the role of the signaling molecule "phospholipase D" (PLD) in increasing the invasiveness and metastatic potential of tumor cells.
Laura Rigsbee, a master's student in Dr. Paliy's lab, received the biochemistry and molecular biology department's Graduate Student Excellence Award for the 2009-10 academic year. Laura is working on a research project that examines the role of intestinal bacteria in human gastrointestinal disorders. She is a first author on a paper submitted for publication, and has also contributed to three poster presentations at...