Three mechanisms assemble central nervous system nodes of Ranvier
February 18, 2015
February 18, 2015
As action potentials propagate along axons, they are regenerated by excitatory domains called nodes of Ranvier. This study uncovered multiple ‘back-up’ molecular mechanisms to assemble nodes, all dependent on the interaction between neurons and myelinating glial cells.
Susuki K, Chang K-J, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto J, Burlingame AL, Seidenbecher C, Zimmermann DR, Oohashi T, Peles E, Rasband MN (2013). Three mechanisms assemble central nervous system nodes of Ranvier. Neuron 78:469-482.
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