Dr. Michael Leffak's Laboratory Published in "Nature Chemical Biology"

Dr. Michael Leffak's laboratory published in Nature Chemical Biology that probing trinucleotide repeat structures using engineered zinc-finger nucleases provides evidence that DNA hairpins form in vivo and are linked to replication-dependent genomic instability. Instability of (CTG)-(CAG) repeats in microsatellite DNA has been linked to numerous neurological diseases.